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phenobarbital will lower the level or influence of olanzapine/samidorphan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Powerful CYP3A4 inducers reduce levels of olanzapine and samidorphan by~50% and ~seventy five% respectively.phenobarbital will minimize the level or outcome of ketoconazole by af